Chuyên đề bồi dưỡng học sinh giỏi toán 6: phương pháp giải toán 6 nâng cao

      26

Biological Activity for 4-P-PDOT

4-P-PDOT is a melatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.

Bạn đang xem: Chuyên đề bồi dưỡng học sinh giỏi toán 6: phương pháp giải toán 6 nâng cao


Compound Libraries for 4-P-PDOT

4-P-PDOT is also offered as part of the angiangtourism.vncreen 2.0 Max. Find out more about compound libraries available from angiangtourism.vn.


Technical Data for 4-P-PDOT

M. Wt 279.38
Formula C19H21NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 620170-78-7
PubChem ID 3976006
InChI Key RCYLUNPFECYGDW-UHFFFAOYSA-N
Smiles CCC(=O)NC1CC(C2=CC=CC=C2)C2=C(C1)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

angiangtourism.vn products are intended for laboratory research use only, unless stated otherwise.


Solubility Data for 4-P-PDOT

Solvent Max Conc. Mg/mL Max Conc. Milimet Solubility
DMSO 27.94 100
ethanol 27.94 100

Preparing Stock Solutions for 4-P-PDOT

The following data is based on the hàng hóa molecular weight 279.38. Batch specific molecular weights may vary from batch lớn batch due lớn the degree of hydration, which will affect the solvent volumes required khổng lồ prepare stock solutions.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.79 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

*When preparing stock solutions always use the batch-specific molecular weight of the hàng hóa found on the vial label và CoA (available online).


The reconstitution calculator allows you lớn quickly calculate the volume of a reagent to lớn reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Xem thêm: Từ 01/7/2020, Tài Xế Cần Nhớ 66 Biển Báo Xe Đạp Không Được Đi Vào


References for 4-P-PDOT

References are publications that support the biological activity of the product.

Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a và Mel1b recombinant subtypes are used khổng lồ assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID:9089668 Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID:7762083 If you know of a relevant reference for 4-P-PDOT, please let us know.


View Related Products by Target


View Related Products by product Action

View all Melatonin Receptor Antagonists


Keywords: 4-P-PDOT, 4-P-PDOT supplier, MT2, antagonists, Receptors, Melatonin, AH024, AH, 024, (MT), 1034, angiangtourism.vn Bioscience


8 Citations for 4-P-PDOT

Citations are publications that use angiangtourism.vn products. Selected citations for 4-P-PDOT include:

Faria et al (2013) Melatonin acts through MT1/MT2 receptors to lớn activate hypothalamic Akt và suppress hepatic gluconeogenesis in rats. Am J Physiol Endocrinol Metab 305 E230 PMID:23695212

Zhao et al (2010) Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol 588 2605 PMID:20519319

Danilova et al (2004) Melatonin stimulates cell proliferation in zebrafish embryo & accelerates its development. J Pharmacol Exp Ther 18 751 PMID:14766799

Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID:28473754


Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. FASEB J 108 625 PMID:11518737

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298 PMID:24574803

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther 336 127 PMID:20959363

Jones et al (2010) Identification of a κ-opioid agonist as a potent và selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID:20696141


vì you know of a great paper that uses 4-P-PDOT from angiangtourism.vn? Please let us know.


Reviews for 4-P-PDOT


There are currently no reviews for this product. Be the first to nhận xét 4-P-PDOT và earn rewards!


Have you used 4-P-PDOT? Submit a nhận xét and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to đánh giá with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a reviews with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a đánh giá without an image


Submit a review

Literature in this Area

angiangtourism.vn offers the following scientific literature in this area lớn showcase our products. We invite you to request* your copy today!

*Please chú ý that angiangtourism.vn will only send literature to lớn established scientific business / institute addresses.


Request copy or Request PDF today">
GPCR sản phẩm Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

Rhodopsin-like Receptors Glutamate Receptors Frizzled Receptors GPCR Signaling
New Products in this Area
GPR52 Comp-43
Cat. No. 7445
GPR52 receptor antagonist
Sign-up for new product e-alerts
Literature in this Area
GPCR product Listing

Highlights over 450 products for GPCRs.

Request copyRequest PDF
*

Submit a review & Earn an Amazon Gift card

You can now submit reviews for your favorite angiangtourism.vn products. Your nhận xét will help other researchers decide on the best products for their research. Why not submit a reviews today?!

Submit reviews
Need help? ×

How can we help you?


Close Start Chat
Corporate
tư vấn
Bio-Techne Brands
Stay Connected

Get the latest news, hàng hóa updates, và promotions:

Sign Up for E-Alerts

Follow angiangtourism.vn: