Chuyên Đề Bồi Dưỡng Học Sinh Giỏi Toán 6: Phương Pháp Giải Toán 6 Nâng Cao
Biological Activity for 4-P-PDOT
4-P-PDOT is a melatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.
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Compound Libraries for 4-P-PDOT
4-P-PDOT is also offered as part of the angiangtourism.vncreen 2.0 Max. Find out more about compound libraries available from angiangtourism.vn.
Technical Data for 4-P-PDOT
| M. Wt | 279.38 |
| Formula | C19H21NO |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 620170-78-7 |
| PubChem ID | 3976006 |
| InChI Key | RCYLUNPFECYGDW-UHFFFAOYSA-N |
| Smiles | CCC(=O)NC1CC(C2=CC=CC=C2)C2=C(C1)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
angiangtourism.vn products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 4-P-PDOT
| DMSO | 27.94 | 100 |
| ethanol | 27.94 | 100 |
Preparing Stock Solutions for 4-P-PDOT
The following data is based on the hàng hóa molecular weight 279.38. Batch specific molecular weights may vary from batch lớn batch due lớn the degree of hydration, which will affect the solvent volumes required khổng lồ prepare stock solutions.
| 1 mM | 3.58 mL | 17.9 mL | 35.79 mL |
| 5 mM | 0.72 mL | 3.58 mL | 7.16 mL |
| 10 mM | 0.36 mL | 1.79 mL | 3.58 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
*When preparing stock solutions always use the batch-specific molecular weight of the hàng hóa found on the vial label và CoA (available online).
The reconstitution calculator allows you lớn quickly calculate the volume of a reagent to lớn reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
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References for 4-P-PDOT
References are publications that support the biological activity of the product.
Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a và Mel1b recombinant subtypes are used khổng lồ assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID:9089668 Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID:7762083 If you know of a relevant reference for 4-P-PDOT, please let us know.
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Keywords: 4-P-PDOT, 4-P-PDOT supplier, MT2, antagonists, Receptors, Melatonin, AH024, AH, 024, (MT), 1034, angiangtourism.vn Bioscience
8 Citations for 4-P-PDOT
Citations are publications that use angiangtourism.vn products. Selected citations for 4-P-PDOT include:
Faria et al (2013) Melatonin acts through MT1/MT2 receptors to lớn activate hypothalamic Akt và suppress hepatic gluconeogenesis in rats. Am J Physiol Endocrinol Metab 305 E230 PMID:23695212
Zhao et al (2010) Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol 588 2605 PMID:20519319
Danilova et al (2004) Melatonin stimulates cell proliferation in zebrafish embryo & accelerates its development. J Pharmacol Exp Ther 18 751 PMID:14766799
Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID:28473754
Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. FASEB J 108 625 PMID:11518737
Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298 PMID:24574803
Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther 336 127 PMID:20959363
Jones et al (2010) Identification of a κ-opioid agonist as a potent và selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID:20696141
vì you know of a great paper that uses 4-P-PDOT from angiangtourism.vn? Please let us know.
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